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wxWidgets

wxWidgets is a C++ library that lets developers create applications for Windows, OS X, Linux and UNIX on 32-bit and 64-bit architectures as well as several mobile platforms including Windows Mobile, iPhone SDK and embedded GTK+. It has popular language bindings for Python, Perl, Ruby and many other languages. Unlike other cross-platform toolkits, wxWidgets gives its applications a truly native look and feel because it uses the platform's native API rather than emulating the GUI. It's also extensive, free, open-source and mature. Why not give it a try, like many others have?

PySide

PySide

The PySide project provides LGPL-licensed Python bindings for the Qt cross-platform application and UI framework. PySide Qt bi ...