Supybot
Nested commands, easy configuration, and an incredibly flexible and easy-to-use plugin system distinguish Supybot from other IRC bots. There simply isn't a more flexible or easier to use IRC bot!
Limnoria
IRC bot based on Supybot. It adds translations (fr, fi, it, hu, de, ...), embedded web server, bug fixes, and several other en ...
eggdrop
Eggdrop is tan Open Source IRC bot, designed for flexibility and ease of use.
Phenny
A Python IRC Bot
Chaskis
Chaskis - A generic framework for making IRC Bots.A generic framework written in C# for making IRC Bots. Supports plugins, con ...